Scientific Literature

Abstract

Objective: Osseointegration has been a proven concept in implant dentistry and orthopedics for decades. Substantial efforts for engineering implants for reduced treatment time frames have focused on micrometer and most recently on nanometer length scale alterations with negligible attention devoted to the effect of both macrometer design alterations and surgical instrumentation on osseointegration. This manuscript revisits osseointegration addressing the individual and combined role of alterations on the macrometer, micrometer, and nanometer length scales on the basis of cell culture, preclinical in vivo studies, and clinical evidence.

Methods: A critical appraisal of the literature was performed regarding the impact of dental implant designing on osseointegration. Results from studies with different methodological approaches and the commonly observed inconsistencies are discussed.

Results: It is a consensus that implant surface topographical and chemical alterations can hasten osseointegration. However, the tailored combination between multiple length scale design parameters that provides maximal host response is yet to be determined.

Significance: In spite of the overabundant literature on osseointegration, a proportional inconsistency in findings hitherto encountered warrants a call for appropriate multivariable study designing to ensure that adequate data collection will enable osseointegration maximization and/or optimization, which will possibly lead to the engineering of endosteal implant designs that can be immediately placed/loaded regardless of patient dependent conditions.

Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales

Paulo G. Coelhoa, Ryo Jimbod, Nick Tovar, Estevam A. Bonfantee

http://dx.doi.org/10.1016/j.dental.2014.10.007

Architectural

Design: 1

It’s not marketing fiction.

It’s evolutionary science.

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Company Overview. Intra-Lock History.

Bio-active Surface.

OSSEAN®, nano-profilometry and

calcium impregnated surface is found

on all Intra-Lock implants. Numerous

scientific papers have been published

on OSSEAN® reporting the remarkable

performance of this surface.

Learn More >

The Cutting Edge.

BLOSSOM® technology (patent pending) cuts through bone with the efficiency of a knife. Lowered insertion torque results in decreased micro-movement. Seats like nothing you’ve ever experienced.

Learn More >

Better Healing From Within.

Learn More >

IntraSpin™, a FDA cleared medical device for

the production of L-PRF™, has opened a new

world of enhanced healing possibilities

for patients.

Premiere Implant System

Solid Strength &

Precise Connection.

GOLD&BLUE™

Restorative simplicity.

One connection for ALL implant diameters...

one very special implant system.

Learn More >

Specific Designs Encourage Physiologic Harmony.

InDex™ has multiple implant architectures, both

Tapered and Straight Bodies, included in this internal

connection implant system. Diameters from 3.4mm

to 6.5mm address a wide variety of clinical

applications and all feature the biologically

active OSSEAN® Surface.

Learn More >

Designed for Extraction Site

& Immediate Placement.

EnvisionOS™

At last...an implant specifically designed to maximize stability in immediate extraction sites.

Learn More >

Compatible with Internal

Hex Configurations

Now the technological advances found in Intra-Lock’s InDex™ Internal Connection Implant bodies are available on a wide selection of implants…with an internal–hex abutment connection.

Learn More >

Small Diameters...

BIG FEATURES.

MDL®

Excellent for longterm denture stabilization, this

premier small diameter system features one-step

delivery, Cement-Over Abutments, multiple thread

designs and OSSEAN® bio-active surface.

Learn More >

A True “Convertible”...

3.0mm Implant System.

MILO® is a true convertible implant with

one-piece solid strength and two-piece versatility. The Cement-Over Abutments™ provide an unsurpassed range of prosthetic options.

Learn More >

Universal Hex Connection.

Unihex™

A traditional External Hex prosthetic configuration with many of the technological advances found in Intra-Lock’s Internal Connection Implant Systems. Single

connection for all 3 prosthetic tables.

Learn More >

One-Piece Implant System

One-Piece™OP is a one-piece dental implant

designed for single tooth replacement or short-span

fixed prostheses where parallelism can be readily

achieved. As with all Intra-Lock® dental implants,

OP features the bio-active surface; OSSEAN®

Learn More >

One-Piece Implants.

Developed over the years into a simple, yet predictable procedure, thousands of patients have benefited from the FlatOne® treatment modality. The streamlined FlatOne® System and Protocol enable both the dentist and the laboratory technician to work together in a highly efficient, closely coordinated manner.

Full-arch Fixed Prosthesis,

Not a Hybrid Denture

Reduces Chair-side Time & Laboratory Costs

Case Time Condensed

(to as little as 48 hours)

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Eliminate Intermediate

Abutments

Over the years, thousands of patients have benefited from FlatOne® treatment modality; a full-arch restorative solution with dentition emerging from the soft tissue…not a hybrid denture.

FlatTop™ One-Piece Implants incorporate FlatOne® Abutments with the architectural enhancements and bio-active performance of the OSSEAN® surface BLOSSOM® Implants. This design maximizes overall strength, simplifies. placement and condenses restorative inventory.

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Screw Retained

Abutment System

Intra-Lock offers an optional abutment

system ideal for multiple unit screw-retained restorations.

Ease of retrievability and versatility make the Conic Abutment an excellent option in full arch restorations. Conic Abutments can be fitted with bars, metal, zirconia or polymer framework.

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Scientific Literature

Architectural

Design: 1

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Miscellaneous Research

It’s not marketing fiction.

It’s evolutionary science.

Company Overview. Intra-Lock History.

Bio-active Surface.

OSSEAN®, nano-profilometry and

calcium impregnated surface is found

on all Intra-Lock implants. Numerous

scientific papers have been published

on OSSEAN® reporting the remarkable

performance of this surface.

The Cutting Edge.

BLOSSOM® technology (patent pending) cuts through bone with the efficiency of a knife. Lowered insertion torque results in decreased micro-movement. Seats like nothing you’ve ever experienced.

Better Healing From Within.

IntraSpin™, a FDA cleared medical device for

the production of L-PRF™, has opened a new

world of enhanced healing possibilities

for patients.

Premiere Implant System

Solid Strength &

Precise Connection.

GOLD&BLUE™

Restorative simplicity.

One connection for ALL implant diameters...

one very special implant system.

Specific Designs Encourage Physiologic Harmony.

InDex™ has multiple implant architectures, both

Tapered and Straight Bodies, included in this internal

connection implant system. Diameters from 3.4mm

to 6.5mm address a wide variety of clinical

applications and all feature the biologically

active OSSEAN® Surface.

Designed for Extraction Site

& Immediate Placement.

EnvisionOS™

At last...an implant specifically designed to maximize stability in immediate extraction sites.

Compatible with Internal

Hex Configurations

Now the technological advances found in Intra-Lock’s InDex™ Internal Connection Implant bodies are available on a wide selection of implants…with an internal–hex abutment connection.

Small Diameters...

BIG FEATURES.

MDL®

Excellent for longterm denture stabilization, this

premier small diameter system features one-step

delivery, Cement-Over Abutments, multiple thread

designs and OSSEAN® bio-active surface.

A True “Convertible”...

3.0mm Implant System.

MILO® is a true convertible implant with

one-piece solid strength and two-piece versatility. The Cement-Over Abutments™ provide an unsurpassed range of prosthetic options.

Universal Hex Connection.

Unihex™

A traditional External Hex prosthetic configuration with many of the technological advances found in Intra-Lock’s Internal Connection Implant Systems. Single

connection for all 3 prosthetic tables.

One-Piece Implant System

One-Piece™OP is a one-piece dental implant

designed for single tooth replacement or short-span

fixed prostheses where parallelism can be readily

achieved. As with all Intra-Lock® dental implants,

OP features the bio-active surface; OSSEAN®

One-Piece Implants.

Eliminate Intermediate

Abutments

Screw Retained

Abutment System

CONIC

DIGITAL SOLUTIONS

Intrabase

The Titanium Base Kit for

Intra-Lock Implant Systems

Precision + Accuracy =